Biochemical Principles

In developing The Nootropic Multi emphasis was placed on:

(relating to heart health and neurotransmitter balance)

*Mitochondrial Dysfunction
(relating to the energy pathways in the body)

*Phase I, II and III liver detox
(phase III often being overlooked in supplement design)

*Amygdala interaction with the prefrontal cortex [i]
(the part of the brain that kicks in whilst in fight-or-flight mode, and how this affects the "seat of consciousness" in the brain; Reacting vs Responding)

*NMDA receptor modulation [ii]
(and how this relates to anxiety)

*Kynurenine pathway
(relating to serotonin production)

*Agmatine supplementation [iii]
(neurotransmitter function and its relationship to depression and addiction)

*Estrogen Dominance
( how it relates to health of body and emotions)

*Going back to basics

*Ratios, balance, synergy

*Keeping things simple

*Keeping things as free from side-effects as possible




The chemical reactions in the body try to maintain a balance within themselves. During the daily activities of the body nutrients are metabolized through a biological-chemical process by adding or subtracting other molecules to them. Changing the structure of the original nutrient results in changing its function in some way, and this is how the body produces all the things one needs to live.

These two compounds (the original substrate and its resulting product) can be interchanged, converting from one to the other, in a state of chemical balance. This balance is known as homeostasis, or metabolic equilibrium. 

Here is an example of such a reaction:

DGL and DGA are physiologically interchangeable, being able to convert back and forth to remain balanced in a 50/50 ratio within the body.  


This flux between two states is tightly controlled in the body. When these biochemical reactions are disrupted, such as when toxins enter into the system, the bodily balance gets thrown out of whack, which can lead to all sorts of dis-ease.

The human body is a miracle of creation. The philosophy behind the development of the nootropic has always been that if you give the body what it needs, it will heal itself. 

This is why stimulant or depressant ingredients were avoided in the design process - there's no need to artificially manipulate biochemical pathways, simply provide the body with the raw materials it requires and let it work its own magic. 

Another principle used in making this nootropic was to simplify supplementation by putting everything in one, in as few capsules as possible.  

So what you have with The Nootropic Multi is an all-in-one solution that covers fundamentally important aspects of metabolism, as well as providing you with a concentration of the best smart-nutrients for your brain.

Taken with a magnesium supplement at night, The Nootropic Multi covers most (if not all) of your day-to-day supplementation needs. 

We'd go so far as to say this is the best multinutrient ever made. 

The Nootropic Multi: its what your brain needs. 


“Deep inside the skull of every one of us there is something like a brain of a crocodile. Surrounding the R-complex is the limbic system or mammalian brain, which evolved tens of millions of years ago in ancestors who were mammal but not yet primates. It is a major source of our moods and emotions, of our concern and care for the young. And finally, on the outside, living in uneasy truce with the more primitive brains beneath, is the cerebral cortex; civilization is a product of the cerebral cortex.”

— Carl Sagan, Cosmos p.276–277



[i] Reference: Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation.
Nelson H Donegan 1, Charles A Sanislow, Hilary P Blumberg, Robert K Fulbright, Cheryl Lacadie, Pawel Skudlarski, John C Gore, Ingrid R Olson, Thomas H McGlashan, Bruce E Wexler

[ii] Reference: Hippocampal NMDA receptors and anxiety: At the interface between cognition and emotion
Christopher Barkus,a,⁎ Stephen B. McHugh,a Rolf Sprengel,b Peter H. Seeburg,b J. Nicholas P. Rawlins,a and David M. Bannermana,

[iii] Reference: Agmatine as a novel candidate for rapid-onset antidepressant response.
Ana Paula Valverde, Anderson Camargo, and Ana Lúcia S Rodrigues

[iii] Reference: Agmatine Prevents Adaptation of the Hippocampal Glutamate System in Chronic Morphine-Treated Rats
Xiao-Fei Wang 1, Tai-Yun Zhao 1, Rui-Bin Su 1, Ning Wu 2, Jin Li 3